Motor and sensory features successfully decode autism spectrum disorder and combine with the original RDoC framework to boost diagnostic classification

نویسندگان

چکیده

Abstract Sensory processing and motor coordination atypicalities are not commonly identified as primary characteristics of autism spectrum disorder (ASD), nor they well captured in the NIMH’s original Research Domain Criteria (RDoC) framework. Here, sensory features performed similarly to RDoC support vector classification 30 ASD youth against 33 typically developing controls. Combining with boosted performance, achieving a Matthews Correlation Coefficient (MCC) 0.949 balanced accuracy (BAcc) 0.971 ( p = 0.00020, calculated permuted null distribution). alone successfully classified (MCC 0.565, BAcc 0.773, 0.0222) clinically relevant control group 26 Developmental Coordination Disorder (DCD) were fact required decode DCD above chance. These findings highlight importance phenotype their relevance

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2021

ISSN: ['2045-2322']

DOI: https://doi.org/10.1038/s41598-021-87455-w